Nature paper: 10M-cell immune multiome atlas from 1,108 FinnGen donors links disease variants to regulation
anshulkundaje · x · 2026-10-01
A Nature paper led by Masahiro Kanai presents a population-scale single-nucleus immune multiome atlas: 10M PBMCs from 1,108 FinnGen donors, profiled at the Broad Institute with chromatin accessibility and gene expression measured in the same nuclei.
The study connects GWAS disease-associated variants to gene regulation and disease risk by mapping them onto specific immune cell types and regulatory programs, providing a major public resource for understanding the regulatory mechanisms of autoimmune and other immune-related diseases.
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