Stanford Qi Lab Wins NIH TRDNT Challenge Phase I With Spatial RNA Reprogramming Platform

anshulkundaje · x · 2026-10-01

Stanford's Qi lab and collaborators won Phase I of the NIH TRDNT Challenge with a project on Spatial RNA Reprogramming.

• The premise: mislocalized RNA may drive disease, so redirecting RNA to the right place could open new treatment paths
• Built on CRISPR-TO, the platform redirects selected RNAs without editing the genome
• First goal: restore RNA localization to improve neuronal function in ALS models
• The proposal was led by Maylin Fu, with NIH recognition marking the first of multiple phases

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