Anshul Kundaje: trained LLMs could break the genomic motif annotation bottleneck

anshulkundaje · x · 2026-09-24

• Stanford researcher Anshul Kundaje clarified the discussion is less about motif discovery and more about biologically annotating motifs — what they do, what they bind to.
• He sees it as a multi-modal reasoning task LLMs could excel at with some training, which would unlock a massive bottleneck in genomic sequence annotation, currently a painstaking manual process.
• Part of the same thread on Mythos activations resembling genomic language model features.

Related event: Stanford team finds frontier LLMs like Opus 5 and GPT6 poor at DNA motif annotation out of the box(6 posts)→

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