BindCraft2 protein design suite launches with full open-source code, free for academic and industry use
mmbronstein · x · 2026-09-21
PacesaLab released BindCraft2 ahead of its paper, open-sourcing the full code on GitHub the same day, free for both academic and industry use, explicitly to let researchers apply it to the ongoing Adaptyv protein design competition.
- Unified workflow: combines de novo miniproteins, scaffolded binders, cyclic peptides and multistate design; users describe a target, pick a binder modality and specify properties, with named presets supplying design settings and acceptance filters.
- Pipeline: sequence optimization via AlphaFold 2 plus ProteinMPNN redesign, candidate evaluation with separate AlphaFold models and structural filters, returning sequences, predicted complexes and ranked results with interface, fold and molecular property metrics.
- Caveat: authors note these are computational designs — binding, selectivity and requested properties still require experimental validation.
Related event: BindCraft2 Released: Code Open-Sourced Same Day, Free for Commercial Use(5 posts)→
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