Human Organoids Fill 91.9% of Cortex in Engineered Mice, Nature Paper Reports
ctjlewis · x · 2026-09-18
A new Nature paper from Sergiu Pasca's team describes genetically engineered "apallial" mice lacking a cortex, into which the researchers transplanted organoids derived from human neural cells after birth.
- Three months later, the cortex was 91.9% human-derived neural cells by volume in measured animals
- Commenters (incl. Nita Farahany) stress these are still mice, nothing like humans, with no evidence of human-like experiences
- One viral repost quipped that we've finally created Algernon from Flowers for Algernon
The model promises major value for neurological disease modeling and drug discovery.
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