Johns Hopkins preprint finds 3,022 recursive splice sites in the human genome
anshulkundaje · x · 2026-09-14
A bioRxiv preprint led by PhD student David Bass in Steven Salzberg's lab at Johns Hopkins introduces a new method for detecting recursive splice sites (RSSs) by aligning total RNA-seq data to short custom target sequences.
- Recursive splicing removes an intron in two or more splicing events rather than one
- Applied to a human brain gene-expression dataset with a very low false discovery rate, the method found 3,022 RSSs across 2,775 introns in 2,407 genes
- 96% (2,891) of these RSSs sit in protein-coding genes
- Recursively spliced introns have a median length of 10,114 bp — longer than the median human intron but much shorter than prior RS estimates
- The work dramatically expands the known RSS catalog and ships a generalizable annotation pipeline
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