Upstream gene dominance: supercoiling-mediated repression gates downstream activation
anshulkundaje · x · 2026-09-13
- Galloway Lab shared technical follow-up on their gene syntax work, corroborating Philippe Batut's enhancer observations.
- They mapped the effect to supercoiling-mediated repression: the downstream gene stays off while the upstream gene is active, and only becomes activatable once the upstream gene shuts off.
- Batut's co-visualization of eRNA and mRNA found gene activation coincides with a drop in enhancer transcription, with optimal activation at low enhancer activity — consistent with an "eRNA priming" model.
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