AIxBio researcher: skip the bitter lesson debate — more compute means lower per-dollar efficiency
anshulkundaje · x · 2026-09-10
Researcher Sam Sinai followed up on his GPN-Star commentary, preempting Bitter Lesson-style objections.
- Core claim: at this point it's simply "whoever has more money deploys more compute and sometimes achieves more — with far lower per-dollar efficiency," as the paper itself illustrates.
- AlphaFold: cited as proof that "some cleverness + lots of scale" can still achieve great things.
- The era: "we are in the tail end of human cleverness mattering, so let's enjoy the show of people like Yun while we can."
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