Euchromatin isn't 'open': live-cell imaging reveals condensed domains insulated by cohesin
arjunrajlab · x · 2026-09-08
- A new Nature Genetics study from Kazuhiro Maeshima's lab uses super-resolution live-cell imaging to challenge the classic view that euchromatin is simply "open" chromatin.
- In living human cells, euchromatin actually forms condensed domains rather than a uniform open state.
- Cohesin constrains these domains and prevents them from mixing locally, providing proper transcriptional insulation.
- The findings reshape our understanding of genome folding and the spatial organization of gene regulation.
More from Research
- Elias Bareinboim's IPAM lecture on interpretability now online — yudapearl · 2026-09-08
- ECCV 2026 MUCG workshop lineup: unified multimodal MLLMs and three new papers — mohitban47 · 2026-09-08
- ECCV 2026 AI4VA workshop reveals 14 accepted papers, Björn Ommer among keynote speakers — ducha_aiki · 2026-09-08
- 277-page 'Foundations of Large Language Models' textbook released free on arXiv, covering pre-training to inference — leslysandra · 2026-09-08
- Lightweight prompt injection detector: MiniLM + logistic regression, F1 just 61.6% on adversarial benchmark — Worldly_Yoghurt8850 · 2026-09-08
- ARC-AGI-N: open-source tool surfaces unsolved science problems and preps context for your AI agent — Physical_Pepper6294 · 2026-09-08