Testing GPT Sol on de novo RNA design for the RNA World Hypothesis, with wet-lab validation
chaitjo · x · 2026-09-05
AI-for-science researcher chaitjo shares testing the Rosalind Workbench on whether an LLM alone—no other design models as tools—can read literature, reason about geometry, and create de novo RNA designs for the RNA World Hypothesis, via @eternagame's new Replicase design challenge.
- The goal: design an RNA that copies both itself and other RNAs, kickstarting evolution. The problem has rich literature and reasonably accurate 3D structures.
- Crucially, designs will be prospectively tested in the wet lab — "this is not a benchmark"; no one knows the answers or what makes a good design.
- Eterna also gives participants a care package of key scientific resources.
- A contest runs alongside: coolest Rosalind Workbench project after its first week wins a free year of ChatGPT Pro.
Related event: Researchers Test Whether LLMs Can Design Self-Replicating RNA from Scratch(2 posts)→
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