Nature Biotech paper: reference materials as common calibrator to make multiomics data AI-ready

kshameer · x · 2026-09-03

A Nature Biotechnology paper (Leming Shi, Christopher E. Mason, et al.) argues that poor reproducibility of multiomics measurements undermines AI tools. The authors propose adopting reference materials as a common calibrator co-profiled with study samples, and reporting multiomics results as sample-to-reference ratios so data become reproducible across labs and platforms — and therefore suitable as reliable inputs for artificial intelligence.

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