Researcher Warns Agent-Extracted Features Can Leak Outcome Labels Via Frontier Models

anshulkundaje · x · 2026-08-22

A technical exchange between genomics researcher Anshul Kundaje and a paper author over label leakage in agent-extracted features. The author says evidence-extraction agents are separated from training and evidence is checked for outcome-label leakage. Kundaje counters that if features come from trials a frontier model has already seen, the model can inject outcome information into any feature map regardless of agent separation, and leakage is hard to check in abstract embeddings. He suggests a time-horizon split: test only on trials released after the frontier model's training cutoff.

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