Physicist: most AI-for-science startups will die, but mining existing literature is the real win

skdh · x · 2026-08-18

Responding to Simon Maechling's thread that AI will mostly accelerate disappointment in science, physicist Sabine Hossenfelder offers a split verdict.

Where she agrees: Most AI-science startups will go bankrupt within a few years, especially those betting on new materials discoveries — she knows someone selling materials-science data to companies, and companies simply won't buy it, doing all testing in-house. Startups catering to academia also have no real money to make.

Where she disagrees: Current AI systems are ideally suited to exploit untapped potential in the existing literature. Thousands of discoveries likely lie in connecting dots across papers that no single human can overview — exactly what AI is good at.

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