AI for Science: Designing mRNA Sequences with Evo 2 and Other Models

BrianHie · x · 2026-08-13

Therna shared their practice in AI-driven biological sequence design. Treating RNA as a language that can be read and rewritten, they combined tools like Evo 2, PARADE, EnCodon, and ViennaRNA within the Proto framework to design a glucagon mRNA for HepG2. The results are currently for illustrative purposes and lack wet lab validation.

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