Human Bindome: Open-Sourcing Protein Binder Candidates for Every Human Protein
jajoosam · x · 2026-08-03
Human Bindome is a proteome-scale atlas of designed protein binder candidates, aiming to provide an open-source binder for every human protein.
- Scale: Contains over 300,000 (306,146) computationally designed binder candidates covering 8,296 human proteins (>40% of the proteome).
- Motivation: Traditional antibody reagents are often expensive, variably characterized, and lack disclosed sequences, leading to reproducibility issues. This project provides openly specified alternatives.
- Methodology: Candidates were generated using the experimentally benchmarked BindCraft pipeline. Each is 90 amino acids long and comes with an explicit sequence, a predicted binder-target complex structure, and in silico confidence metrics.
- Resources: The project is open-source on GitHub, accompanied by a Hugging Face dataset, an interactive website, and an MCP server for seamless integration.
The author calls for wet-lab efforts (e.g., phage display or yeast display) to verify the on-target activity of these candidates.
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