Single-cell multiomics links 3D genome changes to Alzheimer’s disease
jmuiuc · x · 2026-07-26
Single-cell multiomics study links 3D genome changes to Alzheimer’s disease
The paper combines multiple modalities to study Alzheimer’s disease, including:
- GAGE-seq combining Hi-C and RNA
- snATAC-seq
- Xenium
- integrated multiscale analysis and predictive modeling
According to the figure, the study compares AD vs non-AD and highlights:
- compartment mingling increases in AD
- regulatory architecture shifts with altered short-range and mid-range regulation
- downstream changes in gene expression
- a framework that connects 3D genome features, gene regulation programs, and spatial organization
The diagram also shows Hicformer being used to predict gene expression from DNA sequence plus 3D features, alongside spatial transcriptomic analysis of the microenvironment and ligand-receptor interactions.
Related event: Science Study Reveals 3D Genome Restructuring in Alzheimer's(4 posts)→
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