Science paper maps single-cell 3D genome rewiring in Alzheimer’s disease
jmuiuc · x · 2026-07-24
The authors share a Science paper on single-cell 3D genome reorganization in Alzheimer’s disease.
What the study did:
- Jointly measured gene expression and 3D genome architecture in individual human brain cells using GAGE-seq.
- Integrated those measurements with chromatin accessibility and spatial transcriptomics.
- Found increased compartment mingling and distance-dependent rewiring of gene regulatory contacts in Alzheimer’s disease.
The paper also introduces Hicformer, a transformer-based model that combines DNA sequence with 3D genome features to:
- predict cell type-specific gene expression,
- prioritize candidate regulatory elements.
The post credits the co-first authors and collaborators across Carnegie Mellon, Pitt, and Rush.
Related event: Science Study Reveals 3D Genome Restructuring in Alzheimer's(4 posts)→
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