Science paper links Alzheimer’s to single-cell 3D genome rewiring and Hicformer
jmuiuc · x · 2026-07-24
A Science paper reports single-cell 3D genome reorganization in Alzheimer’s disease.
The team jointly measured gene expression and 3D genome architecture in individual human brain cells, then integrated chromatin accessibility and spatial transcriptomics. They found increased compartment mingling and distance-dependent rewiring of gene-regulatory contacts in AD. They also introduced Hicformer, a transformer-based model that combines DNA sequence and 3D genome features to predict cell-type-specific gene expression and prioritize candidate regulatory elements.
Related event: Science Study Reveals 3D Genome Restructuring in Alzheimer's(4 posts)→
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