COMPASS Builds Interpretable Concept Bottleneck Transformer Using 132 Gene Signatures
marinkazitnik · x · 2026-07-03
At its core, COMPASS features a concept bottleneck design: after encoding the tumor transcriptome, it processes the data through a Transformer bottleneck layer comprising 132 gene signatures (aggregated into 44 interpretable immune and stromal concepts) to ultimately predict treatment response. By basing decisions on human-readable biological concepts rather than latent features, the model ensures strong clinical interpretability.
More from Research
- NUS builds a soft force sensor that drives actuators without electronics or power — CurieuxExplorer · 2026-07-27
- Chelsea Finn says robot RL is bottlenecked by physical rollout cost, not algorithms — ycombinator · 2026-07-27
- ICML 2026 oral paper replication scores stay middling after a stricter re-scoring — profjamesevans · 2026-07-27
- Long-running agents will need immutable event logs, this thread argues — sebpaquet · 2026-07-27
- Seed IQ navigates Doom II, prompting questions about benchmarks beyond ARC-AGI — Fit_Transition8824 · 2026-07-27
- Agentic Data Science in Practice: Agents Write Code but Answer Wrong Questions — hugobowne · 2026-07-27