COMPASS Builds Interpretable Concept Bottleneck Transformer Using 132 Gene Signatures
marinkazitnik · x · 2026-07-03
At its core, COMPASS features a concept bottleneck design: after encoding the tumor transcriptome, it processes the data through a Transformer bottleneck layer comprising 132 gene signatures (aggregated into 44 interpretable immune and stromal concepts) to ultimately predict treatment response. By basing decisions on human-readable biological concepts rather than latent features, the model ensures strong clinical interpretability.
More from Research
- Nature paper images cellular activity across all organs, revealing body-wide circuits — arjunrajlab · 2026-09-11
- SignNet 1M Dataset Released for Sign Language Research — ducha_aiki · 2026-09-11
- ECCV26 Oral: Flow Matching Enables Single-Stage Multi-View Point Cloud Registration — ducha_aiki · 2026-09-11
- InFlux++ Method Released — ducha_aiki · 2026-09-11
- Skyfall GS Uses Flux to Refine Gaussian Splatting, Accepted at ECCV 2026 — ducha_aiki · 2026-09-11
- Could 10k agents discover learning methods beyond backprop, or just tweak existing ones? — SeunghyunSEO7 · 2026-09-11