Nature Genetics study finds one-third of TWAS gene-disease association directions are wrong

A Nature Genetics study finds that about one-third of gene effect directions inferred by TWAS are wrong, raising concerns for drug target strategies based on such associations.

2026-10-25 ~ 2026-10-27 · 2 related posts

• TWAS false sign rates hit 33% for complex traits, Nature Genetics study finds — zakkohane · 2026-10-25
• TWAS Study: ~33% of Disease-Gene Direction Calls Are Discordant, Misleading Drug Targets — anshulkundaje · 2026-10-27