Theis and Kundaje Debate Phenotype-First Perturbation Modeling
Fabian Theis and Anshul Kundaje discussed training objectives for AI perturbation prediction, agreeing that phenotype prediction is better-defined than gene-level reconstruction and is best done in a cleaner latent space given noisy single-cell measurements.
2026-10-10 ~ 2026-10-10 · 4 related posts
- Cell fate predictions need not reconstruct every gene, given noisy single-cell data — anshulkundaje · 2026-10-10
- AI-for-science debate: phenotype readouts matter more than gene-by-gene reconstruction — fabian_theis · 2026-10-10
- Kundaje: model perturbation effects in latent space to dodge noisy single-cell data — anshulkundaje · 2026-10-10
- Computational biologists urge reconstructing key biological axes in latent space — anshulkundaje · 2026-10-10