Greg Isenberg's 49-point playbook for building an AI-native company

FinanceYF5 · x · 2026-11-15

A Chinese recap thread of Greg Isenberg's 49-point playbook for AI-native companies: turn company knowledge into AI memory, repetitive work into Skills, and let agents execute and improve continuously — covering knowledge bases, skills, agent orchestration, automated production, and growth.

The opening segment covers building a usable company "brain": second-brain your thinking and decisions in Obsidian Markdown; capture voice notes with Wispr for agent-archived facts and decisions; centralize clients, finance, pricing, processes, and past decisions in a company knowledge base; use Granola to record meetings with transcripts auto-written into the base.

Related event: Greg Isenberg shares 49 rules for building an AI-native company(12 posts)→

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