Stanford's iISM microscope images living cells at 120nm without fluorescent labels
MacrinePhD · x · 2026-11-15
Stanford researchers built Interferometric Image Scanning Microscopy (iISM), combining two advanced microscopy techniques to achieve 120 nm resolution live-cell imaging without fluorescent labels that can perturb cell behavior.
- Enables simultaneous real-time observation of multiple cellular structures moving and responding to their environment
- Could reveal how cells interact with drugs and disease-causing organisms, with implications for cancer and infectious disease research
- Published in a Nature Portfolio journal
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