AI-derived ClinicalAge from EHRs correlates with cancer and chronic disease risk
EricTopol · x · 2026-11-13
Eric Topol shares a Lancet Digital Health study: ClinicalAge, an AI-derived metric from longitudinal electronic health records, diverges widely from chronological age and correlates with disease risk.
Key findings from two large cohorts (UK Biobank, CPRD):
- Associated with 11 cancer diagnoses, strongest for lung, liver, oesophageal and pancreatic cancer (HR up to 1.3)
- Also linked to 20 non-cancer diseases, with diabetes, COPD, chronic liver disease, heart failure and CKD showing HRs of 1.3-1.5+
- Suggests the metric could serve as an early-warning signal across multiple conditions
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