BioSecBench-Structure: 58 evaluations benchmarking agents' molecular reasoning for biosecurity
kenbwork · x · 2026-11-13
BioSecBench-Structure is a structural reasoning benchmark for biosecurity tasks, measuring how well AI agents interpret molecular structures to assess pathogen targets and support development of vaccines, antibodies, and drugs.
- It comprises 58 evaluations built from crystal and cryo-EM structures, predicted models, and experimental measurements.
- Task breakdown: 33 on threat characterization, 22 on countermeasure design, and 3 on threat detection.
- Example tasks include determining how many receptor-binding domains are open across nine cryo-EM structures of coronavirus spike conformations, and screening inhibitors against a bacterial pathogen using two pilus-assembly protein structures as templates.
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