Study: 100% of ~100k people carry at least one medication-affecting genetic variant
EricTopol · x · 2026-11-12
Eric Topol highlights a Science Translational Medicine pharmacogenomics study using whole-genome sequencing and EHR data from 100,000 All of Us participants across 16 pharmacogenes. Key findings: 100% carried at least one pharmacogenomic variant affecting drug response and 99.5% had an actionable predicted phenotype — yet almost nobody knows their variants; 24.4% had both an actionable phenotype and prior exposure to an impacted medication; thousands of previously unrecognized variants were found, especially in American and African ancestry populations, underscoring unmet potential of precision prescribing.
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