DeepMind launches AlphaGenome 2, a DNA model predicting variant effects per cell type
demishassabis · x · 2026-11-12
Google DeepMind announced AlphaGenome 2, a new DNA sequence model that predicts the impact of genetic variants in specific cell types, helping scientists understand why a single-letter DNA change drives disease in some cells but not others.
- Improves cell-type specificity over v1, generalizes to users' own scRNA-seq data, and imputes unobserved modalities
- Ships with the AlphaGenome Atlas: genome-wide in silico mutagenesis across 9 billion variants with pre-computed scores and an AVI (AlphaGenome Variant Impact) score, accessible via a zero-code website and API
- Free API access for non-commercial academic research
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