DeepMind releases AlphaGenome 2 with precomputed impact scores for 9B variants
anshulkundaje · x · 2026-11-12
Google DeepMind released AlphaGenome 2 and the AlphaGenome Atlas:
- AG2: improved cell-type specificity, generalizes to users' own scRNA-seq data, imputes unobserved modalities — positioned as a bridge between human genetics and cell biology.
- Atlas: genome-wide in silico mutagenesis across 9 billion variants with precomputed scores and the new AlphaGenome Variant Impact (AVI) score for coding and noncoding variant prioritization, available via a zero-code site and API.
- Code, Python API, E2G & GWAS atlases, and the preprint are public; the API is free for non-commercial use.
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