AlphaGenome2 hits SOTA linking distal enhancers to target genes from gradients
anshulkundaje · x · 2026-11-12
adamgayoso reports that AlphaGenome2 (AG2) can link distal enhancers to their target genes from input gradients of predicted expression, reaching SOTA on CRISPRi screens: 0.78 AUPRC vs. 0.73 for AG1 and 0.57 for ENCODE-rE2G across 5 cell lines, and 0.68 vs. 0.58 (EGrf) in human astrocytes. The figure shows the gradient-based enhancer-gene scoring strategy and per-distance breakdowns.
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