DeepMind unveils AlphaGenome 2, predicting DNA variant effects across hundreds of cell types
pushmeet · x · 2026-11-11
Google DeepMind introduced AlphaGenome 2, its next-generation genomics model that deciphers how DNA changes affect cells. The key architectural change: predictions are conditional on cell types and states, enabling variant-effect predictions across hundreds of human cell types and adaptation to unseen cell and disease states without retraining. On the TenK10K immune cell dataset it showed a major accuracy leap over its predecessor, reliably identifying near-pathogenic variants — a step toward uncovering the cellular drivers of disease.
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