Claude agent drives a real Leica microscope via MCP, autofocus and all
jwt0625 · x · 2026-11-11
The tweet jokes about using a QWERTZ keyboard, but the screenshot is the real story: a Claude agent connected through an MHP Bridge is controlling an actual Leica microscope.
Visible in the screenshot:
- The agent reads the hardware docs, then explains the autofocus procedure: a coarse Z sweep (±20µm, 2µm steps) followed by a fine sweep (±0.5µm, 0.5µm steps), scoring each frame by Laplacian variance and driving the real focus motor to the best Z via the AWM bridge;
- It runs shell commands on its own, works around an isopen attribute error, and invokes the autofocus routine through the rig's MCP server;
- A Live View panel shows the camera feed and live DMG microscope hardware telemetry.
A vivid demo of AI agents stepping out of software and into controlling physical lab equipment.
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