Geodesic's NovaAtom-Lite hits 79% on FoldBench antibody-antigen prediction, beating AlphaFold 3's 48%
QuanquanGu · x · 2026-11-11
Geodesic Intelligence released NovaAtom-Lite, an all-atom structure prediction model for drug discovery: given protein, DNA, RNA chains plus small-molecule ligands, it predicts every heavy atom with pLDDT/PAE/ipTM confidence outputs.
Key results (FoldBench antibody–antigen, DockQ ≥ 0.23, same 2021-09-30 training cutoff as AlphaFold 3, 5 seeds × 5 samples):
- NovaAtom-Lite: 79.07% (n=172)
- IsoDDE: 75.58%
- AlphaFold 3: 47.90% (n=167)
Strengths focus on interfaces that matter for drug discovery. Available via Geodesic API and NovaDDE.
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