NovaAtom-Lite hits 79% on FoldBench antibody-antigen prediction vs AlphaFold 3's 48%
QuanquanGu · x · 2026-11-11
Geodesic launched NovaAtom-Lite, an all-atom structure prediction model for drug discovery that predicts structures of proteins, nucleic acids, and their bound molecules, including how they fit together. On the FoldBench antibody–antigen benchmark (DockQ ≥ 0.23), it scores 79.07% (n=172), vs IsoDDE's 75.58% and AlphaFold 3's 47.90% (n=167). Evaluation uses 5 seeds × 5 samples with top-1 picked by the model's own ranking score. Available now via the Geodesic API and NovaDDE.
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