Holon-S1, never trained on osteosarcoma, still matched the real treatment target
iScienceLuvr · x · 2026-11-10
据转述，Holon-S1 was never trained on osteosarcoma and had never seen an osteosarcoma patient. Yet when SophontAI ran a real patient's diagnosis slide through the model, it flagged the same target the patient was eventually treated with before going into remission.
iScienceLuvr walks through the case, highlighting striking out-of-distribution generalization of a general reasoning model into a specialized medical domain.
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