Cortical organoid platform screens 1,280 compounds across 6,000+ organoids at 7,000/hour
anshulkundaje · x · 2026-11-10
- The Pasca lab released a bioRxiv preprint describing a simple, cost-effective, scalable platform for high-throughput screening in human cortical organoids.
- The setup uses a compact plate washer/dispenser that fits inside a standard biosafety cabinet and processes medium changes for over 7,000 organoids per hour, drastically cutting labor for large-scale culture.
- Using it, the team screened 1,280 compounds targeting major signaling pathways across 6,000+ organoids, identifying translational regulation as a key mechanism governing cell-state transitions.
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