Krishnaswamy Lab open-sources Neurospectrum, a geometric-topological DL framework for neural trajectories

Pseudomanifold · x · 2026-11-09

Krishnaswamy Lab released Neurospectrum on GitHub (Bhaskar, Zhang, Moore et al.): a geometric and topological deep learning framework that models neural activity as a time-varying signal on a graph, encodes spatial patterns with multiscale diffusion wavelets plus learnable attention, and compresses them via a T-PHATE-regularized autoencoder into low-dimensional latent trajectories. Code, notebooks and configs are public; validated on mouse calcium imaging and human fMRI.

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