Krishnaswamy Lab thread: t-PHATE-regularized autoencoder encodes brain-state temporal evolution

Pseudomanifold · x · 2026-11-09

Part 8 of the Krishnaswamy Lab thread on brain-state modeling: a Temporal-PHATE-regularized autoencoder (Busch et al. 2023) compresses spatial embeddings into a low-dimensional latent trajectory that reflects both the similarity of brain states and their temporal ordering.

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