Immunology thread: for ME/CFS and Long COVID, flare triggers aren't disease causes

alvelda · x · 2026-11-08

An immunology Substack thread challenges how symptom flares in ME/CFS and Long COVID are interpreted: exertion, infection, poor sleep or stress can worsen symptoms, which has long been used to suggest a psychological origin. But the same factors trigger flares in well-understood inflammatory diseases — suggesting we've confused what triggers a flare with what causes the disease.

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