Geneticist pushes back: rare disease bottleneck is causal variants, not human time
anshulkundaje · x · 2026-11-07
In a debate with Daniel McNinnon on AI for rare disease, Anshul Kundaje argues the #1 bottleneck is identifying causal variants, genes and mechanisms — most never characterized, and neither humans nor LLMs can reason their way through unknown mechanisms. Both need computational and experimental tools that remain limited; LLMs help reconcile variant scores and build causal narratives.
Related event: Stanford professor argues rare disease bottleneck is biology, not AI(10 posts)→
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