Stanford's CORAL model on Nature Genetics unifies multiscale spatial omics data
james_y_zou · x · 2026-11-07
James Zou's lab at Stanford published CORAL in Nature Genetics: a probabilistic deep generative model that uses graph attention to integrate spatial transcriptomic, proteomic, metabolomic and epigenomic data across spatial scales. CORAL jointly models high-resolution low-coverage and low-resolution genome-wide datasets, infers niches and cell-cell interactions, and imputes missing data. Applied to spatial transcriptomics + proteomics, it identified cell populations linked to immunotherapy resistance in liver cancer. Code is open-sourced.
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