RFD4-Proteina binders: 158 of 188 designs bound TrkA under 1 µM, vs 18 of 60 for best alternative

AllThingsApx · x · 2026-11-06

A reading group announcement for RFD4-Proteina revealed striking wet-lab results: 158 of 188 computationally designed binders bound the TrkA receptor below 1 µM, while the next best method achieved only 18 of 60. Nate Corley and @DidiKieran will present the details in HannesStaerk's Zoom reading group at 2pm ET / 8pm CET, with Q&A open to attendees.

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