De novo multistate interface design lets protein assemblies switch between geometries
DaveJuergens · x · 2026-11-05
A new bioRxiv preprint from King Lab, led by Dr. Chelsea Fries, establishes multistate interface design as a strategy for engineering protein assemblies that break symmetry and switch between distinct geometries. The figure shows the same designed components self-assembling into 7-fold, mixed, and 5-fold symmetric rings/cages — a new design paradigm for dynamic protein machines and controllable assembly.
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