New study: Grad-CAM localizes chest X-ray findings at 0.575 vs radiologists' 0.888

zakkohane · x · 2026-11-05

Saliency maps — the go-to 'explainable AI for images' method — take another hit. A new study comparing DenseNet-121 and ViT-B16 attribution methods against radiologist annotations finds Grad-CAM localizes findings far less often than radiologists (hit rate at most 0.575 vs 0.888). Validated on an NIH internal test set (21,834 radiographs, 5,161 patients) plus external CheXpert (Stanford) and VinDr-CXR (Hanoi) data, the study covers localization, explanation shift, and failure detection.

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