François Chollet: modeling brain wiring as an engineering problem constrained by genome size and time

CatAstro_Piyush · x · 2026-11-04

François Chollet frames neural development as an engineering problem: write a program a single cell executes to build itself into a brain, small enough to fit in a genome and fast enough to finish within developmental time. He argues the obvious strategies fail at scale for algorithmic reasons — the genome can't store per-synapse wiring, and blind axon search takes too long — pushing designs toward solutions resembling the developmental strategies organisms actually use. That the same solution structure emerges from scaling limits as from evolution suggests some features of neural development may be algorithmically inevitable.

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