Stanford team's FAST-MaP maps RNA structure per-nucleotide in under a week with no sequencer
chaitjo · x · 2026-11-02
Stanford researchers Jigyasa Verma, Hamish Blair, Wipapat Kladwang and Rhiju Das (HHMI) posted the FAST-MaP preprint on bioRxiv.
- FAST-MaP (Fast and Accessible Sequencing Technology for Mutational Profiling) delivers per-nucleotide RNA structure chemical mapping using only standard molecular biology equipment — no in-house sequencing infrastructure or bioinformatics pipeline required.
- The authors report a complete end-to-end workflow in under a week, sharply lowering the barrier to RNA structure probing.
- Use cases span non-coding RNA function, mRNA stability and translation, relevant to structural biology, virology and molecular therapeutics.
- Data and code are released; doi: 10.64898/2026.09.22.753544.
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