Scientists Ask Anthropic and OpenAI to Deorphanize a Wishlist of GPCRs
MaxUnfried · x · 2026-10-31
zetaglobin posted a wishlist of receptors they'd like AI labs to completely and unambiguously deorphanize, including GPR27, GPR85, GPR173, GPR83, GPR141, GPR35, GPR61, GPR88, GPR176, GPR21, GPR75, and GPR50 — all G-protein coupled receptors.
Max Unfried added context: many receptors remain "orphan," meaning their ligands are unknown. He was wowed by the phenomenon years ago while researching estrogen- and cannabinoid-related GPCRs, and would like GPR55, GPR18, and GPR119 deorphanized as well. The exchange highlights the AI-for-science community's expectation that AI can accelerate fundamental biology by inferring unknown ligands.
More from Research
- Neural Picture Alchemy: TMLR paper recasts deep learning as equations solved by backprop — CatAstro_Piyush · 2026-10-31
- KAIST ranks No.2 globally by first-author institutions at NeurIPS 2026 — JungWooHa2 · 2026-10-31
- Graph cuts' golden era in computer vision overlapped with AlexNet, not ancient history — _onionesque · 2026-10-31
- Anthropic study: experts defer to AI agents' leanings 86% of the time — akbirthko · 2026-10-31
- ChatGPT cites a 2025 paper by Kolmogorov, briefly confusing users about the famous mathematician — _onionesque · 2026-10-31
- High schooler's "Image-Space Rule Discovery" paper accepted to ACCV 2026 — HirokatuKataoka · 2026-10-31