Center-biased models shift variant effect predictions by position
anshulkundaje · x · 2026-10-31
Continuing the sequence model discussion, Anshul Kundaje notes that center-biased models predict variant effects differently depending on the variant's position relative to sequence context — underscoring why variants are centered and adequate jitter is needed when scoring.
Related event: Genome Sequence Models Need 500bp Jitter to Remove Center Bias(4 posts)→
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