Three TenK10K papers publish in Nature, profiling 9M PBMCs from 1,925 donors to decode disease genetics
anshulkundaje · x · 2026-10-29
- Three TenK10K papers published simultaneously in Nature.
- The study led by Angli Xue integrates gene expression and chromatin accessibility from 9 million PBMCs across 1,925 donors, tackling the "missing regulation" puzzle of complex human disease.
- Key question: how genetic variants shape single-cell chromatin accessibility and thereby disease risk.
- Open access; among the largest single-cell genetic regulation studies to date.
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