CellBridge: EPFL trains H&E image models to identify cells using spatial transcriptomics

mo_lotfollahi · x · 2026-10-26

EPFL researchers released the CellBridge preprint. H&E slides reveal tissue architecture and cell appearance but often can't distinguish cell types (e.g., T vs B lymphocytes) without extra markers, while spatial transcriptomics provides molecular detail but is much harder to obtain routinely. CellBridge trains an image model on 1 million cells with paired H&E images and Xenium spatial transcriptomics, using molecular measurements to teach visual recognition of cell identity.

Related event: EPFL Releases CellBridge: Predicting Single-Cell Gene Identity from H&E Slides(2 posts)→

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