DeepMind's AlphaProtein Novo designs enzymes nature never evolved, from drugs to plastic breakdown
hey_abusiddik · x · 2026-10-24
Google DeepMind unveiled AlphaProtein Novo, a pipeline that uses generative AI to design enzymes for chemical reactions nature never evolved — synthesizing drug molecules like piperidine and hydrolyzing DEHP plastic pollutants.
- The team says it's the first machine-learned pipeline to achieve practically relevant catalytic rates for de novo non-natural chemistry from first principles
- Designed transferases outperform natural enzymes on pharmaceutically relevant substrates
- The paper argues de novo enzyme design is becoming a powerful complement to natural enzyme diversity for discovering catalysts
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